The challenges and obstacles to including flow cytometry in multi-center clinical trials are well-known. The solutions the KCAS team offers can eliminate risks commonly associated with lost or delayed shipments and allow for batching, which reduces the overall cost of conducting flow cytometric testing. As a result, our customers can receive answers quickly and efficiently, without delays or hassles of further qualification or rigid timelines.
KCAS offers 13 prequalified biomarker immune monitoring panels for support of clinical trials. These panels allow our clients to quantify patient’s T cells, B cells, Natural Killer (NK) Cells, Dendritic Cells, T cell receptors, memory cells, intracellular regulatory biomarkers, intracellular cytokines, ALL cancer cells, CLL cancer cells, and MM cancer cells. These panels can be used to help determine the mechanism of action of a compound and/or to monitor the safety of a treatment.
Offering prequalified panels saves our clients time and money by avoiding development lead time and fees. The panels can be custom designed for inclusion of additional CD Biomarkers to further meet our client’s needs. However, what really separates KCAS from other labs is we also provide solutions for shipment and storage by qualifying the panels in a preservative with stability at room temperature for up to 14 days.
We recently saved a customer ~$50,000 by utilizing our flow expertise by qualifying the immune monitoring T Cell, B Cell, and NK cell panel (TBNK) panel in a preservation tube that demonstrated 14 days of stability at room temperature storage which allowed for batching of samples. Since the study was a Phase II multi-center clinical trial, the 14 days of stability allowed for convenient sampling collection while patients visited the clinic between Monday – Friday. Additionally, we custom tailored the TBNK panel by adding biomarkers CD2 and CD25 for further enumeration of circulating lymphocytes.
Contact us if your flow cytometry project needs a custom solution and you’d like to explore alternatives to the traditional, expensive and problematic ways getting it done.