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		<title>Novel Approach for an Endogenous Compound</title>
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		<pubDate>Fri, 09 Jul 2010 17:35:37 +0000</pubDate>
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				<category><![CDATA[case studies]]></category>

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Problem: Since the FDA guidance on method validation does not  permit stripping of matrix to remove endogenous compounds, assays for  these analytes hinge on finding depleted matrix for system calibration  (preparation of standards and QCs). In the case of Citric Acid,  exceedingly high levels exist in human urine.

Proposal: In consultation with [...]]]></description>
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